Protein Details: Aquaporin-0

Protein ID

ICDB_Pro_1086

Protein Name

Aquaporin-0

Gene Name

MIP; AQP0

Organism

Ovis aries (Sheep)

Length

263 amino acids

AlphaFoldDB

AF-Q6J8I9-F1-model_v4.pdb

Function

Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity).

Sequence

MWELRSASFWRAIFAEFFATLFYVFFGLGASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAICYVVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFLLFPRLKSVSERLSILKGTRPSESNGQPEVTGEPVELKTQAL

PDB Structures

1SOR 2B6O 2B6P 3J41 3M9I 8SJX 8SJY

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 149: "Important for water channel gating"; SITE 246: "Interaction with BFSP1"; SITE 250: "interaction with BFSP1";

Disease

Location

Detected in eye lens (at protein level)

DOI ID

10.1038/nature02503; 10.1016/j.jmb.2004.07.076; 10.1038/nature04321; 10.1038/emboj.2010.68; 10.1038/nsmb.2630

RefSeq

NP_001153230.1